Symbol
Name
ID

Prkcd
protein kinase C, delta
MGI:97598

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Reduced natural killer cell activity

Absent isohemagglutinin level

Increased circulating antibody level

Autoimmune hemolytic anemia

Decreased proportion of class-switched memory B cells

Decreased proportion of memory B cells

Increased proportion autoreactive unresponsive CD21-/low B cells

Increased B cell count

Autoimmune thrombocytopenia

Lymphoproliferative disorder

Elevated erythrocyte sedimentation rate

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with PRKCD

autoimmune lymphoproliferative syndrome type 3

Mouse Phenotypes

increased B cell apoptosis

increased B cell proliferation

enlarged spleen

increased transitional stage B cell number

abnormal plasma cell differentiation

increased erythrocyte cell number

decreased neutrophil cell number

increased follicular B cell number

increased marginal zone B cell number

increased B cell number

increased NK cell number

increased spleen germinal center number

abnormal neutrophil physiology

abnormal immunoglobulin level

increased IgA level

increased IgG1 level

increased IgM level

Availability

Mouse Genotype

Prkcd^m2Btlr/Prkcd^m2Btlr

Prkcd^tm1.1Chou/Prkcd^tm1.1Chou

Prkcd^tm1Kin/Prkcd^tm1Kin

Prkcd^tm1Msg/Prkcd^tm1Msg

Prkcd^tm1Qxu/Prkcd^tm1Qxu

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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